منابع مشابه
Targeting Disease through Metabolism
The links between cellular and systemic metabolism and different pathologies, including cancer, are on the rise. Cell editor Lara Szewczak asked Doug Green, Ralph DeBerardinis, and Mark Febbraio about what the prospects are for being able to target metabolism therapeutically. An annotated excerpt of the conversation appears below, and the full conversation is available with the article online.
متن کاملTargeting cancer metabolism.
The understanding that oncogenes can have profound effects on cellular metabolism and the discovery of mutations and alterations in several metabolism-related enzymes--isocitrate dehydrogenase 1 (IDH1), isocitrate dehydrogenase 2 (IDH2), succinate dehydrogenase (SDH), fumarate hydratase (FH), and pyruvate kinase M2 (PKM2)--has renewed interest in cancer metabolism and renewed hope of taking the...
متن کاملTargeting Phospholipid Metabolism in Cancer
All cancers tested so far display abnormal choline and ethanolamine phospholipid metabolism, which has been detected with numerous magnetic resonance spectroscopy (MRS) approaches in cells, animal models of cancer, as well as the tumors of cancer patients. Since the discovery of this metabolic hallmark of cancer, many studies have been performed to elucidate the molecular origins of deregulated...
متن کاملMiR-570 inhibits cell proliferation and glucose metabolism by targeting IRS1 and IRS2 in human chronic myelogenous leukemia
Objective(s): Chronic myelogenous leukemia (CML) is a chronic myeloproliferative disorder characterized by the accumulation of myeloid cells with a chromosomal translocation known as the Philadelphia chromosome. In this study, we investigated the roles of miR-570 in CML development. Materials and Methods: Expression of miR-570 in CML samples and cell lines was determined by qRT-PCR. Glucose upt...
متن کاملCell Death Induction by Targeting Tumor Metabolism
Over the last century, a broader interest in the topic of tumor metabolism has emerged. From the 1920s onward, when Otto Warburg proposed increased aerobic glycolysis of tu‐ mor cells, a deeper understanding has established that tumor cells have an altered metab‐ olism which is directly linked to cancer progression. It was soon discovered that not only do environmental changes lead to alteratio...
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ژورنال
عنوان ژورنال: Nature Reviews Urology
سال: 2017
ISSN: 1759-4812,1759-4820
DOI: 10.1038/nrurol.2017.34